Extracellular bioelectrical lexicon: detecting rhythmic patterns within dermal fibroblast populations
Félix, R.
;
Medeiros, M. C. R.
;
Elamine, Y.
; Power, D.
;
Gomes, H.L.
Scientific Reports Vol. 15, Nº 1, pp. 1 - 11, August, 2025.
ISSN (print):
ISSN (online): 2045-2322
Scimago Journal Ranking: 0,90 (in 2023)
Digital Object Identifier: 10.1038/S41598-025-15071-Z
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Abstract
This study uses a bioelectronic-based method to establish how non-electrogenic cells, like dermal fibroblast, employ bioelectrical signals to convey information. Electrophysiology using large-area Multielectrode Arrays (MEAs) devices revealed how populations of non-electrogenic cells in vitro generate patterns of bioelectrical signals. The period of the bioelectrical patterns depends on cell population activity. In a fully formed, healthy monolayer, bioelectrical activity is minimal. But during the formation of a monolayer, signals appear randomly, with a dominant period of 4.2 min. Occasionally, quasi-periodic bursts occur with a period between 1.6 and 2 min. When a mechanical wound is inflicted and during subsequent monolayer repair, quasi-periodic signal bursts occur, with an average period ranging from 60 to 110 min. The study uncovers a short-range non humoral communication system and a lexicon of bioelectrical signals linked to cell states.
