Electrooculography is a technique for measuring the corneo-retinal standing potential of the
human eye. The resulting signal is called the electrooculogram (EOG). The primary applications are
in ophthalmological diagnosis and in recording eye movements to develop simple human–machine
interfaces (HCI). The electronic circuits for EOG signal conditioning are well known in the field of
electronic instrumentation; however, the specific characteristics of the EOG signal make a careful
electronic design necessary. This work is devoted to presenting the most important issues related to
the design of an EOG analog front-end (AFE). In this respect, it is essential to analyze the possible
sources of noise, interference, and motion artifacts and how to minimize their effects. Considering
these issues, the complete design of an AFE for EOG systems is reported in this work.