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Bioelectrical Signal Detection Using Conducting Polymer Electrodes and the Displacement Current Method

Inácio, P. ; Mestre, A. G. ; Medeiros, M. C. R. ; Asgarifar, S. ; Elamine, Y. ; Canudo, J. ; Santos, J. ; Bragança, J. ; Morgado, J. ; Biscarini, F. ; Gomes, H.L.

IEEE Sensors Journal Vol. 17, Nº 13, pp. 3961 - 3966, July, 2017.

ISSN (print): 1530-437X
ISSN (online):

Journal Impact Factor: 1,610 (in 2008)

Digital Object Identifier: 10.1109/JSEN.2017.2703834

Conducting polymer electrodes based on poly
(3, 4 ethylenedioxythiophene):polystyrene sulfonate were used
to record electrophysiological signals from autonomous cardiac
contractile cells present in embryoid bodies. Signal detection was
carried out by measuring the displacement current across the
polymer/electrolyte double-layer capacitance, and compared with
voltage detection. While for relatively low capacitance electrodes,
the voltage amplification provides higher signal quality, and
for high capacitive electrodes, the displacement current method
exhibits a higher signal-to-noise ratio. It is proposed that the
displacement current method combined with high capacitive
polymer-based electrodes is adequate to measure clusters of
cells and whole organs. Our approach has a great potential in
fundamental studies of drug discovery and safety pharmacology