The purpose of this work is to present a novel design and application for a printed Magneto-Electric Dipole (MED) antenna with a directional pattern and high gain intended for use in the n78-5G NR frequency band implementations. Indeed, the MED antenna should have a resonance frequency of 3.5 GHz and work within the 3.3 to 3.8 GHz range. The electric and magnetic dipoles as well as a reflector ground structure have been formed on an FR4 substrate with a thickness of 1 mm. The manufactured antenna has a 10 dBi stable gain in its frequency band. It also exhibits a S 11 of less than -25 dB at a resonance frequency of 3.5 GHz. As a result, a quad Multiple-Input/Multiple-Output (MIMO) structure is designed and fabricated in accordance with the physical specifications of its electrical and mechanical container and the requirements for the application. The fabricated quad-MIMO antennas covering the frequency range of 3.27 to 3.83 GHz achieve 10 dBi gains. As a result of quad-MIMO antennas' unidirectional radiation patterns, there is a greater than 10 dB contrast between the co- and cross-polarized radiation patterns in the main direction of the antenna. Furthermore, aligned and vertical antennas provide isolation of more than 16 dB. The single-element and quad-MIMO MED antennas are analyzed in Computer Simulation Technology (CST) Studio Suite, a high-frequency simulator software.