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Polymer-based scaffolds for neural stem cell culture

Morgado, J. ; Sordini, L. ; Garrudo, F. ; Rodrigues, C. A. V. ; Ferreira, F.C.F.

Polymer-based scaffolds for neural stem cell culture , Proc European Materials Research Society (E-MRS) - Spring Meeting - E-MRS, Nice, France, Vol. , pp. - , May, 2019.

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Stem cell culture is of paramount importance in tissue engineering and regenerative medicine. Neural stem cells or mesenchymal stem cells therapies have the potential to treat neurodegenerative diseases, either by replenishing the cell pool or through the secretion of paracrine factors. In order to successful apply these therapies, we need to develop appropriate scaffolds that, by mimicking the extracellular matrix to culture cells in vitro and control their fate, offers the prospects to turn these in vitro studies into efficient medical processes.
We have been studying the use of conjugated polymers substrates for neural stem cells cultivation and/or differentiation using patterned devices [1]. In addition to the thin film-based scaffolds, the use of polymeric fibers, prepared by electrospinning, based on various polymers, including blends with conjugated polymers, is also being explored.
In this communication we report on our progress in the search for polymer based films and fibers scaffolds, including the use of conductive polymers as these offer the possibility to use electrical stimuli, and their ability to sustain viable cell culture.
We acknowledge FCT financial support under the projects NEURON (PTDC/CTM‐CTM/30237/2017) and UID/EEA/50008/2013.
[1] F. Pires, Q. Ferreira, C. A. V. Rodrigues, J. Morgado, F. C. Ferreira, Biochimica et Biophysica Acta General Subjects, 1850, 1158-1168 (2015).