In this paper we describe a simple and versatile method to prepare drug delivery films composed of an ocular drug used in glaucoma treatment, brimonidine, which was encapsulated in a polymer-beta cyclodextrin. The films were developed in order to allow a controlled sequential release during long periods of time. Here we show that by introducing barrier layers of graphene oxide between the drug delivery ones it is possible to delay the brimonidine release for a few days. The time interval between two dosages of drug release will be controlled by adjusting the number and/or thickness of the graphene layers.