In this paper we consider the uplink of a single carrier frequency division multiple access (SC-FDMA) based system, where a set of small-cells coexist with a macro-cell using the same spectrum. To deal with inter-carrier and inter-system interferences we combine interference alignment (IA) precoding, at the transmitters, with iterative decision feedback equalization, at the receivers. IA is used both at the macro cell UTs and small-cells UT to align the interference along a low dimensional subspace at the macro-cell and small-cell receiver, respectively. The results have shown that the proposed receiver structures are robust to the inter-system interferences and are able to efficient separate the macro and small cells spatial streams.