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Validation of a Sympathovagal Balance Model to Evaluate Autonomic Function in Rats using Time-Frequency Analysis

Pinto, R.

Validation of a Sympathovagal Balance Model to Evaluate Autonomic Function in Rats using Time-Frequency Analysis, Proc World Congress on Medical Physics & Biomedical Engineering - IUPESM , Toronto, Canada, Vol. I, pp. 56 - 56, June, 2015.

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Abstract
The Autonomic Nervous System (ANS) activity can be evaluated in humans by using Heart Rate Variability
(HRV) analysis through classical spectral analysis, and more recently by the use of newer techniques by
time-frequency analysis. We have previously shown that Blood Pressure (BP) changes felt in HRV spectrum
can be assessed and possibly isolated using a hybrid methodology in which HR and BP (in particular diastolic
blood pressure) are mixed to produce an instantaneous variation energy plot reflecting the sympathetic and
vagal autonomic activity, in other words, the ANS modulation on Heart Rate and Blood Pressure.
In this work we test the same approach in rats with the objective to validate the use of this methodology using
continuous Blood Pressure recordings to evaluate the ANS changes.
Data were obtained in 20 rats by using telemetry probes implanted in the abdominal cavity and connected to
the abdominal aorta for continuous BP and HR recordings in control situation and also in response to stimuli
that change the autonomic response such as chronic intermittent hypoxia and drug administration.
The results showed that this hybrid methodology allows the evaluation of autonomic nervous system balance
and can be used in laboratory and eventually in clinical settings to evaluate disautonomies