Cardiovascular variability and homeostasis control in response to precise noxious stimuli and different analgesic doses were analyzed. Cardiovascular variability was altered in response to noxious stimulation, and amplitude responses varied in a dose-dependent manner with the analgesic. Responses were more pronounced to laringoscopy/intubation, when compared to tetanic and incision stimuli. Homeostasis control was also altered in response to stimulation, demonstrating that dynamic cardiovascular control relations are modified in response to precise noxious stimuli and anesthetic drugs.