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Texture Analysis of T1-weighted Turbo Spin-Echo MRI for the Diagnosis and Follow-up of Collagen VI-related Myopathy

Rodrigues, Rafael ; Banda, M. ; Tordjman, M. ; Gómez-Andrés, D. ; Quijano-Roy, S. ; Carlier, R. ; Pinheiro, A.

Texture Analysis of T1-weighted Turbo Spin-Echo MRI for the Diagnosis and Follow-up of Collagen VI-related Myopathy, Proc IEEE 18th International Symposium on Biomedical Imaging , Conference Online, Vol. , pp. - , April, 2021.

Digital Object Identifier: 10.1109/ISBI48211.2021.9433942

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Abstract
Muscle texture analysis in Magnetic Resonance Imaging (MRI) has revealed a good correlation with typical histological changes resulting from neuromuscular disorders. In this research, we assess the effectiveness of several features in describing intramuscular texture alterations in cases of Collagen VI-related myopathy. A T1-weighted Turbo Spin-Echo MRI dataset was used (N = 26), consisting of thigh scans from subjects diagnosed with Ullrich Congenital Muscular Dystrophy or Bethlem Myopathy, with different severity levels, as well as healthy subjects. A total of 355 texture features were studied, including attributes derived from the Gray-Level Co-occurrence Matrix, the Run-Length Matrix, Wavelet and Gabor filters. The extracted features were ranked using the Support Vector Machine Recursive Feature Elimination (SVM-RFE) algorithm with Correlation Bias Reduction, prior to cross-validated classification with a Gaussian kernel SVM.