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Noninvasive Detection of Pulmonary Hypertension by Second Heart Sound Shape Analysis

Castro, A. C. ; Mattos, S. S. ; Coimbra, M.

Noninvasive Detection of Pulmonary Hypertension by Second Heart Sound Shape Analysis, Proc Portuguese Conf. on Pattern Recognition - RecPad, Faro, Portugal, Vol. NA, pp. NA - NA, October, 2015.

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Abstract
Heart sound characteristics are linked to blood pressure, and its interpretation is important for detection of cardiovascular disease. In this study, heart sounds acquired from adult patients with (PH, n=11) and without (NPH, n=32) pulmonary hypertension, were analyzed. A novel method is proposed for the second heart sound analysis, and detection of PH. The proposed method automatically segments the phonocardiogram (first and
second heart sounds - S1 and S2), aligning the detected S2s to define the signal envelope for peak-picking and aortic (A2) and pulmonary (P2) components detection (maximum, minimum and difference envelopes). Following, A2 and P2 amplitudes relation was analyzed (P2/A2). The best results in separating NPH from PH patients was obtained using the maximum envelope: NPH: 0.260.12, PH: 0.420.10 (Wilcoxon Mann-Whitney test, p<0.01). The P2/A2 ratio allows to separate the patients with and without PH, and it may be observed that in the NPH group the P2 amplitude rarely surpasses 50% of the A2 amplitude. Larger clinical studies need to be conducted to evaluate the reproducibility of our results. But if proved reliable, this simple algorithm has the potential to allow for
a cost-effective tool to detect PH by S2 shape analysis.