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Project: Just in Time Dendrimers

Acronym: Dendrí­meros
Main Objective:
The work plan on this project envisages the design, preparation and performance evaluation of useful biodegradable and biocompatible dendrimers with targeted physical and chemical properties for two defined applications: (i) in vivo smart “pH-driven” efficient drug nanocarriers and (ii) new chemical sensors. The dendrimers preparation will be performed using an economic, clean, and simple, one-pot procedure, where CO2
is both used as a solvent and as a reagent (C1 feedstock). To exclude dendrimers cytotoxicity and enhance their biodegradability urea linkages will be incorporated in the dendrimer architecture.Another interesting and cutting edge issue in dendrimer chemistry is that these nanometer-sized vehicles will be incorporated within layer-bylayer (LBL) films using alternating hydrogen bond interactions as the driving force for
assembly, thus enabling the incorporation of drugs and pH-sensitive release. The unique architectural features of dendrimers led to fairly recent developments in the field
of chemical sensing. This almost unexplored potential opens-up for exciting opportunities that we will systematically explore: i) using the dendrimers library without end-capping for explosives detection ii) using perylene end-capped dendrimers for detection of metal cations.
Reference: PTDC/CTM/099452/2008
Funding: FCT/PTDC
Start Date: 01-01-2010
End Date: 01-06-2012
Team: Jorge Manuel Ferreira Morgado
Groups: Organic Electronics – Lx
Partners: FCT/UNL
Local Coordinator: Jorge Manuel Ferreira Morgado
Links: Internal Page

Associated Publications